Anti-cancer properties of a fitness lifestyle

Weekend Warrior and the science of anti-cancer fitness

 By Dr. Geo Espinosa

You want a quick way to get hurt, go out Sunday morning and play 2-hours of any sport while your weekdays are sedentary. This has nothing to do with age.

I play pick up basketball games with men over 60 on the weekends. They play well. And hard. And careful. But they are also in shape.

Staying in the game is extremely important both literally and figuratively. We should all find a sport we like and play it for as long as possible. Some members are in this community are in their 70′s and still playing tennis. Sorry, golf don’t count.

Here’s the deal though: you have to train at least three times a week with a nice combination  of full-body weight resistance exercises, some aerobic and a little stretching.

I should to think this was a ” should do.” Now I firmly believe is a “must do.” We always look for excuses not to exercise despite the mounting evidence showing its protective effects – especially in cancer.

Physical activity is the absolute best method to avoid injuries and prevent most diseases .

A plethora of research have shown that not only does exercise significantly decrease the risk of cancer development but increase quality of life and life expectancy after cancer diagnosis.

Summary of the evidence for exercise helping people before cancer

In Prostate Cancer one can reduce their risk up to 20%. (Liu et al. 2011)  One of the benefits of exercising is to reduce the chances of becoming over-weight pr obese. Carrying extra pounds increases the risk of aggressive prostate cancer. (Buschemeyeret al. 2013)

In Breast Cancer there is a 25% reduction in the risk of breast cancer among the most physically active women compared with those who are least active. a 1989 randomized trial of 45 women undergoing adjuvant chemotherapy for stage II breast cancer demonstrated that 10 weeks of interval-based, aerobic exercise not only improved functional capacity and body composition, but it also decreased chemotherapy-induced nausea. This pioneering work demonstrated that aerobic exercise was feasible, safe, and beneficial for patients undergoing chemotherapy. (Winningham et al 1989)

In Kidney Cancer one study looked at  19 studies documenting  a protective association between physical activity and the formation of kidney cancer. (Behrens et al. 2013)

Summary of the evidence of exercise helping people after cancer

Among the most interesting advances in the field of exercise and cancer in the last decade are several observational studies showing that colon, breast, and prostate cancer survivors who exercise enjoy reduced cancer-specific mortality.

One study called the  Cancer and Leukemia Group B (CALGB) 89,803 studied subjects consisted of 832 subjects with stage III colon cancer. These patients were followed prospectively for a about  10 years. Compared with subjects exercising an hour or less per week, those walking at least 6 hours weekly showed  a whopping 49% decreased risk of death over the course of the study (Meyerhardt et al. 2006).

Another large well known study  called the Nurses’ Health Study (NHS) reinforced this finding. Among 573 colon cancer survivors, those who exercised at least 6 hours weekly gained significant cancer-specific survival compared to those exercising less than an hour a week. (Meyerhardt et al. 2006*).

Yet another trial looked at  over 4,500 postmenopausal women with breast cancer who were enrolled in the study, those who walked briskly for only 3 hours a week had a significantly lower risk of overall mortality compared with inactive women. (Irwin et al. 2011)

With prostate cancer one study demonstrated that men who walked briskly for 90 minutes or more each week had a decreased risk of all-cause mortality.  However, ONLY brisk walking failed to decrease the risk of prostate cancer-specific death. Those exercised most intensely for 3 or more hours weekly not only decreased overall mortality compared with just brisk walking, but vigorous exercise also decreased the risk of prostate cancer-related deaths by an impressive 61%. (Kenfield et al. 2011)

Imagine a drug that would decrease the risk of prostate cancer related deaths by 61%? It would be all over the news and stock holders would make millions overnight.

Besides walking, other moderate-intensity exercise modalities in this study included golf and weight lifting. Among the more vigorous exercise modalities in this study were squash, running, swimming, tennis, and bicycling. (Kenfield et al. 2011)

(Again, unless you carry your own golf bag and walk the course, golf is not considered moderate-intensity – at least in my book)

Bottom line and take home message

I have patients, typically those who live in big cities like New York City, trying to convince me that they walk for exercise. Walking, in and by itself does NOT offer maximal protection against most cancers.

The primary reason why exercising is most beneficial is two-fold: 1. controlling excess body fat formation, 2. controlling the over production of insulin.

Walking fails to improve fat build up, insulin resistance, and inflammation. (Trapp et al 2008)

Supervised exercise programs incorporating small volumes of high-intensity activity, such as repeated short sprints, not only decrease fat production but  improve insulin sensitivity and also achieve these results with an hour or less of exercise per week. (Dipietro et al. 2006) T

Here’s another doozy:

Even if one exercise’s with moderate intensity 3 hours a week, but spends the rest of the day sitting, say … in front of a computer, that increases the risk of chronic disease and cancer. So being consistently sedentary even if you exercise is a problem. (Katzmarzyk et al. 2009)

What can you do?

•    Know that walking is not good enough.

•    Don’t be a weekend warrior. It’s OK to be athletic on the weekends but you must train at least two times a week to avoid injuries.

•    Commit to exerting with moderate intensity 3 to 4 hours a week. This can be 30 minutes a day for 6 days or one hour two times a week plus 30 minutes two other days in a week. Make sure you workup a good sweat. The exercise program MUST include weight resistance, aerobic and stretching exercises like yoga – or simply stretching. Equipment  for weight resistance can be anything that you’d can pull and push: your body weight, exercise bands of weights.

•    Your exercise regimen MUST include some activities you don’t like. Some like running but not lifting. Others like lifting and running but not stretching.  All three are important. Sorry. I’m only the messenger.

•    Play a sport. Yes this can be golf but golf does not count for moderate intensity movement. Tennis does, for example.

•    If you have a job that requires you to sit for a long time, set up an alarm every hour to get up and go for a 5 to 10 minute walk. Suggested activities include climbing a flight or two of stairs, stretching, calisthenics, or taking a short walk. Some office workers make a habit of taking all phone calls standing up.

•    Don’t sit at home after work for a prolong period of time watching the tube. An hour is OK. You can even watch a two hour movie but then get up and do something physical.

Lastly, it has to feel good to know that we have some control of our fate, don’t it? Consider that these anti-cancer benefits are only with exercise. Imagine what can happen when we add good eating habits and the smart use of dietary supplements?

The crux of our upcoming retreat is about implementing the research of lifestyle medicine to improve longevity and quality of life in men who have had prostate cancer. Detailed exercise instruction will be provided. CLICK HERE for more information.

Please share this post with friends and family. It may make a difference in their lives.

Have a great weekend!

 

References:

Behrens G Leitzmann MF. The association between physical activity and renal cancer: systematic review and meta-analysis. Br J Cancer. 2013;108:798-811.

Liu Y, Hu F, Li D, et al. Does physical activity reduce the risk of prostate cancer? A systematic review and meta-analysis. Eur Urol. 2011;60:1029-44.

Buschemeyer W.C., Freedland S.J.: Obesity and prostate cancer: epidemiology and clinical implications. Eur Urol 2007; 52: 331-343

Simons CC, Hughes LA, van Engeland M, et al. Physical activity, occupational sitting time, and colorectal cancer risk in the Netherlands cohort study. Am J Epidemiol. 2013;177:514-30.

Katzmarzyk PT, Church TS, Craig CL, Bouchard C. Sitting time and mortality from all causes, cardiovascular disease, and cancer. Med Sci Sports Exerc. 2009;41:998-1005.

George ES, Rosenkranz RR Kolt GS. Chronic disease and sitting time in middle-aged Australian males: findings from the 45 and Up Study. Int J Behav Nutr Phys Act. 2013;10:20.

Winningham ML, MacVicar MG, Bondoc M, et al. Effect of aerobic exercise on body weight and composition in patients with breast cancer on adjuvant chemotherapy. Oncol Nurs Forum. 1989;16:683-9.

[Meyerhardt JA, Heseltine D, Niedzwiecki D, et al. Impact of physical activity on cancer recurrence and survival in patients with stage III colon cancer: findings from CALGB 89803. J Clin Oncol. 2006;24:3535-41.

* Meyerhardt JA, Giovannucci EL, Holmes MD, et al. Physical activity and survival after colorectal cancer diagnosis. J Clin Oncol. 2006;24:3527-34.

Holmes MD, Chen WY, Feskanich D, et al. Physical activity and survival after breast cancer diagnosis. JAMA. 2005;293:2479-86.

Irwin ML, McTiernan A, Manson JE, et al. Physical activity and survival in postmenopausal women with breast cancer: results from the women’s health initiative. Cancer Prev Res (Phila). 2011;4:522-9.[27.]

Kenfield SA, Stampfer MJ, Giovannucci E, Chan JM. Physical activity and survival after prostate cancer diagnosis in the health professionals follow-up study. J Clin Oncol. 2011;29:726-32.

Ballard-Barbash R, Friedenreich CM, Courneya KS, et al. Physical activity, biomarkers, and disease outcomes in cancer survivors: a systematic review. J Natl Cancer Inst. 2012;104:815-40.

Fairey AS, Courneya KS, Field CJ, et al. Effects of exercise training on fasting insulin, insulin resistance, insulin-like growth factors, and insulin-like growth factor binding proteins in postmenopausal breast cancer survivors: a randomized controlled trial. Cancer Epidemiol Biomarkers Prev. 2003;12:721-7.

Pasanisi P, Berrino F, De Petris M, et al. Metabolic syndrome as a prognostic factor for breast cancer recurrences. Int J Cancer. 2006;119:236-8.

Goodwin PJ, Ennis M, Pritchard KI, et al. Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study. J Clin Oncol. 2002;20:42-51.

Kroenke CH, Chen WY, Rosner B, Holmes MD. Weight, weight gain, and survival after breast cancer diagnosis. J Clin Oncol. 2005;23:1370-8.

Tjonna AE, Lee SJ, Rognmo O, et al. Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study. Circulation. 2008;118:346-54.

Laskowski ER. The role of exercise in the treatment of obesity. PM R. 2012;4:840-4.

Wisloff U, Stoylen A, Loennechen JP, et al. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation. 2007;115:3086-94.

Trapp EG, Chisholm DJ, Freund J, Boutcher SH. The effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women. Int J Obes (Lond). 2008;32:684-91. DiPietro L, Dziura J, Yeckel CW, Neufer PD. Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training. J Appl Physiol. 2006;100:142-9.

Stensvold D, Slordahl SA, Wisloff U. Effect of exercise training on inflammation status among people with metabolic syndrome. Metab Syndr Relat Disord. 2012;10:267-72.

Mathivanan S, Ji H, Simpson RJ. Exosomes: extracellular organelles important in intercellular communication. J Proteomics. 2010;73:1907-20.

Bartlett JD, Close GL, MacLaren DP, et al. High intensity interval running is perceived to be more enjoyable than moderate-intensity continuous exercise: implications for exercise adherence. J Sports Sci. 2011;29:547-53.

Guiraud T, Nigam A, Juneau M, et al. Acute responses to high-intensity intermittent exercise in CHD Patients. Med Sci Sports Exerc. 2011;43:211-7.

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